An independent biosphere:

The dream of creating a self-sustaining environment in space has long captivated scientists and engineers. Early concepts focused on closed ecological systems, where plants, microbes, and technology would work in harmony to recycle everything. The most ambitious Earth-based attempt was Biosphere 2, a massive sealed structure built in the late 1980s to explore the viability of life in a closed system. While the project faced significant challenges, including oxygen fluctuations and difficulties in managing its agricultural biome, it provided invaluable lessons on the complexity of balancing biological and technological systems. These historical efforts directly informed the design of the more focused and reliable systems used in orbit today.

A space station is a modern, technologically-driven closed environment, isolated in the vacuum of space. Unlike on Earth, there is no natural atmosphere to breathe, no water cycle, and no simple way to dispose of waste. The Environmental Control and Life Support System (ECLSS) is the technological marvel that solves this problem, engineering a habitable home in orbit by managing the crew's most vital resources: air, water, and waste.
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Biosphere 2
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ISS from the first module to its current configuration.